“Medicine, Health & Everyday Wellness from Japan”
Pylon PL Tablets: What Kind of Cold Does It Help? Dosage, Side Effects, and Safety Tips — Explained by a Pharmacist
Pylon PL Tablets｜What Does It Treat? How to Take & Safety—Explained by a Pharmacist
A balanced “all-in-one” cold medicine for sore throat, fever, and runny nose. If this is your first time, skim the dialogue below to grasp the essentials in minutes.
Designated Class-2 OTC (Japan)
Maker: Shionogi Healthcare
Age: 15 years and over
May cause drowsiness (no driving)
Maker: Shionogi Healthcare
Age: 15 years and over
May cause drowsiness (no driving)
🗣️ Understand Pylon PL via Dialogue
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Patient
My throat hurts, I have a slight fever, and my nose is runny. I want something OTC that helps quickly…
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Pharmacist
For that combo of symptoms, Pylon PL Tablets is a solid option. It targets sore throat, fever, and runny nose with four ingredients in one product.
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Patient
What’s inside? I’m worried about taking something too strong.
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Pharmacist
For pain/fever: Acetaminophen + Salicylamide.
For runny nose/sneezing: Promethazine (antihistamine).
To support analgesia: Anhydrous caffeine.
It’s the same types of four ingredients as the well-known “PL” combo, adjusted for OTC use.
For runny nose/sneezing: Promethazine (antihistamine).
To support analgesia: Anhydrous caffeine.
It’s the same types of four ingredients as the well-known “PL” combo, adjusted for OTC use.
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Patient
How should I take it—before or after meals?
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Pharmacist
Age ≥15: take 2 tablets per dose, 3 times daily, preferably within 30 minutes after meals with water or lukewarm water. Not for under 15 yrs.
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Patient
When will I feel it working?
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Pharmacist
Many people begin to feel relief in about 30–60 minutes. Its strength is addressing fever, pain, and nasal symptoms at the same time.
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Patient
Will it make me drowsy? I need to drive…
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Pharmacist
It may cause drowsiness and dry mouth due to the antihistamine. Do not drive or operate machinery, and avoid alcohol while taking it.
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Patient
I also have plain painkillers at home (like acetaminophen). Can I combine them?
👩⚕️
Pharmacist
Don’t combine. Avoid taking with other cold medicines, pain relievers, sedatives, or antihistamines—including many motion-sickness, allergy, cough, and nasal remedies—because ingredients will overlap.
🧒
Patient
When should I see a doctor instead?
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Pharmacist
If you’ve taken 5–6 doses and don’t feel better, or if you have a high fever, marked fatigue, shortness of breath, or severe throat swelling, stop and seek medical care. If any serious reaction is suspected, discontinue immediately and get help.
This dialogue is a general guide. Suitability depends on your conditions and other medicines.
Who Is It Good For?
Sore throat + low-grade fever Dual action on pain and fever.
Runny nose & sneezing Antihistamine helps block nasal symptoms.
Headache & joint aches For aches associated with colds.
If stubborn cough or phlegm is your main symptom, don’t “stack” other OTCs first—try this alone and reassess (avoid overlapping ingredients).
Directions (Age 15+)
| Single dose | Daily frequency | Timing |
|---|---|---|
| 2 tablets | 3 times per day | Preferably within 30 minutes after meals, with water/lukewarm water |
Not for children under 15 years.
- Push tablets out of the PTP blister; never swallow the sheet itself.
- Onset: commonly 30–60 minutes, varies by person/meal/symptoms.
Ingredients & Roles (per adult daily dose: 6 tablets)
| Ingredient | Amount | Role |
|---|---|---|
| Salicylamide | 648 mg | Relieves pain and fever |
| Acetaminophen | 360 mg | Relieves pain and fever |
| Anhydrous caffeine | 144 mg | Enhances analgesic effect |
| Promethazine methylenedisalicylate | 32.4 mg | Antihistamine—reduces runny nose/sneezing/nasal stuffiness |
Same types of four ingredients as the medical “PL” combo (OTC-appropriate amounts).
Use Safely
Do NOT:
Use with other cold meds, pain relievers, sedatives, or antihistamines (including motion-sickness, allergy, cough/nasal drugs).
Drive or operate machinery after dosing; avoid alcohol.
Do not use for long periods.
Use with other cold meds, pain relievers, sedatives, or antihistamines (including motion-sickness, allergy, cough/nasal drugs).
Drive or operate machinery after dosing; avoid alcohol.
Do not use for long periods.
Side Effects—watch for:
Common: drowsiness, dry mouth, dizziness, nausea.
Rare but serious: anaphylaxis, severe skin reactions (e.g., SJS), liver/kidney dysfunction, interstitial pneumonia, asthma, etc. Stop and seek care if any warning signs appear.
Common: drowsiness, dry mouth, dizziness, nausea.
Rare but serious: anaphylaxis, severe skin reactions (e.g., SJS), liver/kidney dysfunction, interstitial pneumonia, asthma, etc. Stop and seek care if any warning signs appear.
Ask a professional before use if you have:
- Heart, liver, kidney disease, stomach ulcer, glaucoma, or urination difficulties
- Are on other medicines or have allergies to medications
Excipients include lactose (note for lactose intolerance).
Pregnancy & Breastfeeding
- Pregnancy: Avoid self-medication—consult a healthcare professional first.
- Breastfeeding: Small amounts of some components (e.g., caffeine) may pass into breast milk. If concerned, consider avoiding use or keep to the shortest possible duration. If you do use it, taking a dose right after nursing can reduce exposure before the next feed.
- In both cases, don’t use long-term and beware of drowsiness when holding/carrying your baby.
If prioritizing safety, discuss switching to a single-ingredient acetaminophen product under guidance.
Packaging & Approximate Price (Japan)
| Pack size | MSRP |
|---|---|
| 24 tablets | ¥1,350 (tax-incl. ¥1,485) |
| 48 tablets | ¥2,130 (tax-incl. ¥2,343) |
Prices vary by store and timing.
FAQs
Q. Is this the same as the prescription “PL Combination” granules?
A. It uses the same four types of actives (salicylamide / acetaminophen / anhydrous caffeine / promethazine). However, OTC amounts differ from prescription products.
Q. Will it make me sleepy? Is it OK for daytime?
A. Drowsiness is possible. Avoid driving and risky work. Consider timing doses when you don’t need peak alertness.
Q. Can I take it with other painkillers (e.g., acetaminophen, loxoprofen)?
A. No. It already contains pain/fever ingredients. Also avoid combining with other antihistamine products (allergy, motion-sickness, cough/cold, many “nighttime” medicines).
Q. How fast does it work?
A. Often within 30–60 minutes, but it varies by person and meal timing. A practical tip is to take it soon after meals as directed.
Q. How many days can I keep using it?
A. Not for long-term use. If there is no improvement after about 5–6 doses, stop and consult a clinician.
Q. Can children take it?
A. No. It’s for 15 years and older only.
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